Hippocrates may be the first to record the benefits of white willow bark. He did this in the fifth century BC. In 1828, a French pharmacist Henri Leroux and an Italian chemist Raffaele Piria, we were able to separate a compound from the ash-brown bark, called salicin, from the white willow tree [Salix alba]. Since then, salicylic acid, a reactive derivative of salicin, has been further isolated and one of the main components of aspirin has been found in the home.
To be bigger, better, faster, the bodybuilding industry popularizes the concept of "stacking" or combining certain ingredients to take advantage of their synergies. Synergism occurs when the ingredients are combined, and the particular combination of these ingredients provides a greater benefit than if the individual ingredients were obtained separately from one another.
For decades, the ECA stack has been highly regarded for its popularity in the fitness industry. This is a "stacking" that combines ephedra, caffeine and aspirin. Although the ratio of this combination is different, 25 mg of ephedra is usually mixed with 200 mg of caffeine and 325 mg of aspirin. Unfortunately, when the US Food and Drug Administration [FDA] banned the sale of all dietary supplements containing ephedra on February 6, 2004, this combination became very difficult to combine. Although several numerical studies have shown that the controlled dose of ephedra is safe, the FDA has found that ephedra causes "unreasonable risk of illness or injury." On August 17, 2006, after being challenged by the Federal Court of Appeal, the US Food and Drug Administration supported the ephedra ban through a 133,000-page report, citing 19,000 individual adverse reactions. After this dilemma, ephedra substitutes were quickly positioned to combine with caffeine and aspirin.
Conceptually, the ECA stack effectively measures weight loss and energy gain. Certain stimulants, such as ephedra, are known to be "beta receptor agonists," meaning that they can be key to certain genes in the body [by targeting "beta-2 adrenergic receptors" or "ADRB2"]. To unlock the genetic response. The three reactions that are believed to be unlocked are increased levels of norepinephrine, increased levels of adrenaline and increased levels of cyclic adenosine monophosphate [cAMP].
Norepinephrine and adrenaline are very similar. Both are common neurotransmitters in the brain and can also act as hormones in the body. As norepinephrine levels and cAMP levels increase, heart rate increases and glucose release is triggered by energy stored in the body. When taken with caffeine and aspirin, this series of events increases blood flow to muscle tissue and increases body temperature, which has a thermal effect on the body. It is also believed that during this process, the body begins to burn white fatty adipose tissue, appetite is suppressed, and fatigue decreases as the energy level increases.
When a bunch of stimulants and aspirin [or white willow bark] enter the body, a little light [not literally] tells the body that when metabolism begins to increase, it is stimulated. In response, the body begins to produce phosphodiesterase in the cell and produces prostaglandins extracellularly in vitro. Both of these reactions reduced cAMP levels and slowed the increase in metabolism of the ECA stack.
Caffeine reduces cAMP levels by blocking intracellular phosphodiesterase production, while further increasing the body's adrenaline production, which in turn helps to increase cAMP levels. Aspirin [or white willow bark] reduces cAMP levels by blocking the production of extracellular prostaglandins in vitro. Through these specific effects of caffeine and aspirin [or white willow bark], heat production lasts longer, while metabolism maintains a higher rate, causing the body to burn more calories.
Taking a combination of these ingredients before exercise should also help to exercise better, because the body does not fatigue quickly, the muscles will recover, and the feeling will be fresher and faster. All of this, remember, if your calorie intake exceeds the fuel burned by your body every day, then your body is not designed to burn stored fat. Taking dietary supplements can help your body burn more calories, but don't expect your body shape to have significant long-term changes that will not change your diet and exercise habits.
Orignal From: White Willow Bark - Critical Weight Loss (Diet) Assistant
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